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Session: Therapy for Carbapenem-Resistant Organisms in the Real World

311 - Defining the magnitude of desirability of outcome ranking (DOOR) differences in effectiveness of Ceftazidime-Avibactam (CZA) versus Ceftolozane-Tazobactam (C/T) for multidrug-resistant (MDR) Pseudomonas aeruginosa infections in the United States (CACTUS)

Friday, October 18, 2024

10:42 AM – 10:54 AM US PT

Location: 404 AB

Presenting Author(s)

jason M. Pogue, PharmD

Clinical Professor
University of Michigan, College of Pharmacy
Ann Arbor, MI, United States

Slides

Co-Author(s)

Lilian M. Abbo, MD, MBA (she/her/hers)

Professor of Infectious Diseases; Associate Chief Medical Officer in Infectious Diseases
University of Miami Miller School of Medicine, Jackson Health System
Aventura, FL, United States
RA

Renee Ackley, PharmD, BCPS, BCIDP

Infectious Diseases Pharmacist
Atrium Health
Charlotte, North Carolina, United States
Samuel L. Aitken, PharmD, MPH

Clinical Pharmacist Specialist
Michigan Medicine
Ann Arbor, MI, United States
Benjamin Albrecht, PharmD, BCIDP (he/him/his)

Clinical Pharmacy Specialist II in Infectious Disease
Emory University Hospital
Atlanta, Georgia, United States
Ahmed Babiker, MBBS

Assistant Professor
Emory University
Atlanta, GA, United States
RB

Rachel Burgoon, Pharm.D.

Medical University of South Carolina
Charleston, South Carolina, United States
Kimberly C. Claeys, PharmD, PhD (she/her/hers)

Associate Professor
University of Maryland Baltimore
Baltimore, Maryland, United States
BC

Brooke Curry, PharmD

University of Illinois at Chicago
Chicago, Illinois, United States
Kate DeSear, PharmD, BCIDP, AAHIVP, FIDSA (she/her/hers)

Clinical Infectious Diseases Pharmacist
UF Health Shands Hospital
Gainesville, FL, United States
Jason C. Gallagher, PharmD

Clinical Professor
Temple University
Philadelphia, PA, United States
EG

Esther Golnabi, PharmD

UT Southwestern
Dallas, Texas, United States
Sarah B. Green, PharmD, BCIDP, AAHIVP

Clinical Pharmacy Specialist in Infectious Diseases
Emory University Hospital
Atlanta, GA, United States
AG

Alan E. Gross, PharmD

Clinical Assistant Professor
University of Illinois
Chicago, IL, United States
Emily L. Heil, PharmD, MS

Professor
University of Maryland School of Pharmacy
Baltimore, MD, United States
Krutika M. Hornback, PharmD, BCIDP (she/her/hers)

System Pharmacy Coordinator – Antimicrobial Stewardship Clinical Pharmacy Specialist – Infectious Diseases/Antimicrobial Stewardship Residency Program Director, PGY2 Infectious Diseases Residency
MUSC Health
Mt Pleasant, SC, United States
Keith S. Kaye, MD, MPH

Professor of Medicine
Rutgers Robert Wood Johnson Medical School
New Brunswick, NJ, United States
TK

Trieu-Vi Khuu, NA

University of North Carolina
Chapel Hill, North Carolina, United States
Megan Klatt, PharmD, BCIDP (she/her/hers)

Infectious Diseases/Antimicrobial Stewardship Pharmacist
The University of Kansas Health System, KS, United States
EK

Ellen G. Kline, MS

University of Pittsburgh
Pittsburgh, Pennsylvania, United States
Ryan C. Kubat, DO

Assistant Professor
University of Kansas
Kansas City, Kansas, United States
Wesley D. Kufel, Pharm.D., BCPS, BCIDP

Clinical Associate Professor
Binghamton University School of Pharmacy Sciences
Binghamton, NY, United States
AL

Alexander Lepak, MD, FIDSA

Associate Professor
University of Wisconsin School of Medicine and Public Health
Madison, Wisconsin, United States
Conan MacDougall, PharmD, MAS (he/him/his)

Professor of Clinical Pharmacy
University of California San Francisco
San Francisco, CA, United States
AM

Anjali Majumdar, MD

Assistant Professor
Rutgers-Robert Wood Johnson Medical School
New Brunswick, New Jersey, United States
Amy Mathers, MD, D(ABMM) (she/her/hers)

Associate Professor of Medicine and Pathology
University of Virginia
Charlottesville, VA, United States
Erin K. McCreary, PharmD (she/her/hers)

Director of Infectious Diseases Improvement and Clinical Research Innovation
University of Pittsburgh Medical Center
Pittsburgh, PA, United States
William R. Miller, M.D.

Assistant Professor
Houston Methodist Research Institute
Houston, TX, United States
Marguerite Monogue, PharmD

Pharmacist
University of Texas Southwestern Medical Center
Dallas, TX, United States
W. Justin Moore, PharmD, MS, BCPS, BCIDP (he/him/his)

Practice Coordinator, Antimicrobial & Diagnostic Stewardship; ID Clinical Pharmacist
Northwestern Medicine
Chicago, IL, United States
SO

Shannon Olson, BS Pharm,BCIDP

Infectious Diseases Pharmacist
Sinai-Grace Hospital Detroit Medical Center
Detroit, Michigan, United States
JO

Jessica Oxer, n/a

Weill Cornell Medicine
New York, New York, United States
Jeffrey C. Pearson, PharmD (he/him/his)

Advanced Practice Pharmacy Specialist, Infectious Diseases
Brigham and Women's Hospital
Boston, MA, United States
Christine Pham, PharmD, BCIDP

Infectious Diseases Clinical Pharmacist
University of California, Los Angeles; David School of Medicine/University of California, Los Angeles
Los Angeles, California, United States
Paulette Pinargote, MD

Assistant professor/MD
Lousiana State University Health Shreveport
Bossier City, Louisiana, United States
CP

Christopher Polk, MD

Associate Professor
Atrium Health
Charlotte, North Carolina, United States
Michael J. Satlin, MD

Associate Professor
Weill Cornell Medicine
New York, NY, United States
SS

Sarah W. Satola, PhD

Associate Professor
Emory University School of Medicine, Division of Infectious Diseases
Atlanta, Georgia, United States
Sunish Shah, PharmD

ID pharmacist
Antibiotic Management Program, UPMC Presbyterian Hospital, Pittsburgh, PA
Pittsburgh, Pennsylvania, United States
Pranita Tamma, MD, MHS

Associate Professor
Johns Hopkins School of Medicine
Baltimore, MD, United States
Truc Cecilia Tran, PharmD

Research Scientist
Houston Methodist Research Institute
Houston, TX, United States
David van Duin, MD, PhD

Professor of Medicine
University of North Carolina at Chapel Hill
Chapel Hill, NC, United States
MV

Mollie VanNatta, PharmD, BCPS,BCIDP

Clinical pharmacist
Ochsner LSU Health Shreveport
Shreveport, Louisiana, United States
AV

Ana Vega, PharmD

Clinical Hospital Pharmacist- Infectious Diseases
Jackson Memorial Hospital
Miami, Florida, United States
Venugopalan Veena, PharmD

Associate Professor
University of Florida, College of Pharmacy
Gainesville, Florida, United States
MV

Michael P. Veve, PharmD, MPH

Eugene Applebaum College of Pharmacy and Health Sciences
Detroit, Michigan, United States
Walaiporn Wangchinda, MD

Research fellow
University of Michigan College of Pharmacy
Ann Arbor, Michigan, United States
LW

Lucy S. Witt, MD, MPH

Emory University
Atlanta, Georgia, United States
JW

Janet Wu, PharmD

Infectious Diseases Clinical Pharmacist
Cleveland Clinic
Cleveland, Ohio, United States
Ryan K. Shields, PharmD, MS

Associate Professor of Medicine
University of Pittsburgh
Pittsburgh, Pennsylvania, United States

Disclosure(s):

jason M. Pogue, PharmD: Entasis: Advisor/Consultant; GSK: Advisor/Consultant; Melinta: Advisor/Consultant, Grant/Research Support; Merck: Advisor/Consultant, Grant/Research Support; Shionogi: Advisor/Consultant, Grant/Research Support; Venatorx: Advisor/Consultant

Lilian M. Abbo, MD, MBA: No financial relationships to disclose

Renee Ackley, PharmD, BCPS, BCIDP: No financial relationships to disclose

Samuel L. Aitken, PharmD, MPH: Basilea: Advisor/Consultant; bioMerieux: Advisor/Consultant; Melinta: Advisor/Consultant; Shionogi: Advisor/Consultant

Benjamin Albrecht, PharmD, BCIDP: No financial relationships to disclose

Ahmed Babiker, MBBS: Beckman Coulter Inc.: Advisor/Consultant

Rachel Burgoon, Pharm.D.: No financial relationships to disclose

Kimberly C. Claeys, PharmD, PhD: bioMérieux: Advisor/Consultant, Honoraria

Brooke Curry, PharmD: No financial relationships to disclose

Kate DeSear, PharmD, BCIDP, AAHIVP, FIDSA: AbbVie Inc: Advisor/Consultant (Terminated, May 10, 2024); Basilea Pharmaceutica: Advisor/Consultant (Terminated, July 1, 2023); GSK: Advisor/Consultant (Terminated, January 8, 2024); La Jolla (Entasis): Advisor/Consultant (Terminated, July 1, 2023); Melinta Therapuetics: Advisor/Consultant (Terminated, June 21, 2023)

Jason C. Gallagher, PharmD: No financial relationships to disclose

Esther Golnabi, PharmD: No financial relationships to disclose

Sarah B. Green, PharmD, BCIDP, AAHIVP: No financial relationships to disclose

Alan E. Gross, PharmD: Becton Dickinson Co: Advisor/Consultant

Emily L. Heil, PharmD, MS: No financial relationships to disclose

Krutika M. Hornback, PharmD, BCIDP: No financial relationships to disclose

Keith S. Kaye, MD, MPH: Allecra: Advisor/Consultant; CARB-X: Advisor/Consultant; GSK: Advisor/Consultant; Merck: Advisor/Consultant; Shionogi: Advisor/Consultant; Spero: Advisor/Consultant

Trieu-Vi Khuu, NA: No financial relationships to disclose

Megan Klatt, PharmD, BCIDP: No financial relationships to disclose

Ellen G. Kline, MS: No financial relationships to disclose

Ryan C. Kubat, DO: No financial relationships to disclose

Wesley D. Kufel, Pharm.D., BCPS, BCIDP: Merck & Co.: Grant/Research Support (); Shionogi, Inc: Grant/Research Support ()

Alexander Lepak, MD, FIDSA: No financial relationships to disclose

Conan MacDougall, PharmD, MAS: Merck: Grant/Research Support

Anjali Majumdar, MD: No financial relationships to disclose

Amy Mathers, MD, D(ABMM): No financial relationships to disclose

Erin K. McCreary, PharmD: Abbvie: Advisor/Consultant; Basilea: Advisor/Consultant; Ciadara: Advisor/Consultant; Entasis: Advisor/Consultant; Ferring: Advisor/Consultant; GSK: Advisor/Consultant, Honoraria; Melinta: Advisor/Consultant; Merck: Advisor/Consultant; Pfizer: Honoraria; Shionogi: Advisor/Consultant, Honoraria

William R. Miller, M.D.: Merck: Grant/Research Support; UptoDate: Royalties

Marguerite Monogue, PharmD: No financial relationships to disclose

W. Justin Moore, PharmD, MS, BCPS, BCIDP: No financial relationships to disclose

Shannon Olson, BS Pharm,BCIDP: No financial relationships to disclose

Jessica Oxer, n/a: No financial relationships to disclose

Jeffrey C. Pearson, PharmD: inflarx: Advisor/Consultant

Christine Pham, PharmD, BCIDP: No financial relationships to disclose

Paulette Pinargote, MD: No financial relationships to disclose

Christopher Polk, MD: No financial relationships to disclose

Michael J. Satlin, MD: AbbVie: DSMB participant; bioMerieux: Grant/Research Support; Merck: Grant/Research Support; Selux Diagnostics: Grant/Research Support; SNIPRBiome: Grant/Research Support

Sarah W. Satola, PhD: No financial relationships to disclose

Sunish Shah, PharmD: No financial relationships to disclose

Pranita Tamma, MD, MHS: No financial relationships to disclose

Truc Cecilia Tran, PharmD: No financial relationships to disclose

David van Duin, MD, PhD: Merck: Advisor/Consultant (), Grant/Research Support (); Pfizer: Advisor/Consultant (); Qpex: Advisor/Consultant (); Roche: Advisor/Consultant (); Shionogi: Advisor/Consultant (), Grant/Research Support ()

Ana Vega, PharmD: No financial relationships to disclose

Venugopalan Veena, PharmD: No financial relationships to disclose

Michael P. Veve, PharmD, MPH: No financial relationships to disclose

Walaiporn Wangchinda, MD: No financial relationships to disclose

Lucy S. Witt, MD, MPH: No financial relationships to disclose

Janet Wu, PharmD: No financial relationships to disclose

Ryan K. Shields, PharmD, MS: Allergan: Advisor/Consultant; Cidara: Advisor/Consultant; Entasis: Advisor/Consultant; GSK: Advisor/Consultant; Melinta: Advisor/Consultant, Grant/Research Support; Menarini: Advisor/Consultant; Merck: Advisor/Consultant, Grant/Research Support; Pfizer: Advisor/Consultant; Roche: Grant/Research Support; Shionogi: Advisor/Consultant, Grant/Research Support; Utility: Advisor/Consultant; Venatorx: Advisor/Consultant, Grant/Research Support