Assistant Professor
Mayo Clinic
ROCHESTER, MN, United States
Dr. Knoop recieved her Bachelors degree in Biochemistry from Drake University, followed by her PhD in Immunology from Emory University. she then completed postdoctoral training with Rodney Newberry at Washington University School of Medicine in St. Louis. Funded by an NIDDK K01 career development award and NIAID R21 to understand how enteric bacteria translocate from the neonatal gut, she transitioned to the Mayo Clinic in Rochester, MN, where she is currently an Assistant Professor with the Department of Immunology and the Department of Pediatric. Using a novel model of neonatal sepsis resulting from gut-resident pathogens following disrupting of breastfeeding Dr. Knoop and her team studies how gut resident bacteria translocates the gut epithelium resulting in pathogenic bacteremia that recapitulates neonatal sepsis. Using this model of neonatal sepsis, she has developed a robust platform to characterize the immune response to different disseminating pathogens, including E. coli, Group B Streptococcus, Enterococcus faecalis, Enterobacter cloacae, and Klebsiella pneumoniae. The lab seeks to identify the host and bacterial components that contribute to an overwhelming inflammatory response in neonatal sepsis. Additionally, they are interested in the maternal factors transferred in utero or during breastfeeding that regulate pathogen colonization in the neonatal intestine. This work is funded by an R01 from the NIDDK, and can be found in numerous publications.
Disclosure(s): No financial relationships to disclose
169 - Host Factors That Predispose to Sepsis​
Friday, October 18, 2024
3:15 PM – 4:30 PM US PT
399 - Cytokines and Systemic Inflammation During Neonatal Sepsis
Friday, October 18, 2024
3:15 PM – 3:40 PM US PT